When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. Introduction to role Are you ready to lead the charge in pharmacometrics? As a Senior Manager in Clinical Pharmacology and Quantitative Pharmacology (CPQP), you will be at the forefront of PK-PD Modeling and Pharmacometrics (PMX). Your task involves developing and implementing Modeling & Simulation (M&S) plans and strategies, guiding compounds from early-stage trials to post-market phases. Collaborate with cross-functional teams within Alexion R&D, including Clinical Pharmacology, Translational Medicine, and Biostatistics, to enhance our PMX capabilities. Your expertise will drive the continuous improvement of pharmacometrics skills, computational infrastructure, and strategic M&S methodologies across diverse projects and disease areas. Take charge of project-related M&S assignments, whether independently or in collaboration with external PMX CROs. Are you ready to make a difference? Accountabilities Lead M&S strategies/plans as a project leader in cross-functional development teams. Apply brand new M&S methodologies to inform decision-making at crucial achievements. Build quantitative systems biology/pharmacology models with internal teams and external QSP service providers. Conduct population PK, PKPD analyses, clinical trial simulations, and model-based analyses. Initiate and coordinate outsourced M&S activities. Mentor and coach junior M&S scientists and CPQP scientists. Enhance Alexion's internal M&S capabilities through training and new tool evaluation. Prepare population PK/PD reports and regulatory submission documents. Essential Skills/Experience PhD or equivalent experience in quantitative sciences 2+ years of pharmaceutical industrial and/or postdoctoral experience in the related teams of clinical pharmacology, PKPD, and QSP Excellent hands-on knowledge in R and/or SAS, NONMEM Excellent knowledge in Matlab, Mathematica, or other QSP related software or computing platform Under manager’s guidance, to become well versed at analyzing, summarizing, plotting complex data to identify trends important for drug development Track record of applying quantitative system pharmacology methodologies in a drug R&D context Track record of publishing M&S work Experience from PMX approaches in hematology, nephrology, neuromuscular, ophthalmology, bone, endocrinology, oncology, and/or metabolic rare diseases preferred Excellent written and verbal communication skills Desirable Skills/Experience Doctoral degree (PhD or Equivalent training by experience) in clinical pharmacology, pharmacology/cell biology/immunology, or relevant field Background in clinical pharmacology or bioengineering is desired At Alexion, you will find a collaborative culture that encourages innovation and a diverse environment where your contributions are valued. You will have the opportunity to be at the forefront of rare disease research and make a meaningful difference in patients' lives. Ready to lead and inspire? Apply now and take the first step towards a fulfilling career at Alexion, AstraZeneca Rare Disease. #LI-Hybrid Date Posted 02-May-2025 Closing Date 29-Jun-2025 Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact accommodations@Alexion.com. Alexion participates in E-Verify. For over three decades, patients and their caregivers have been at the center of everything we do. Every day, we are inspired to follow the science and think differently to create better outcomes for them and their families. Our mission is driven by understanding who they are as unique individuals, not solely defined by their diseases. We’re a leading rare disease company with a diversified projects. Our pioneering legacy in rare diseases is rooted in being the first to translate the complex biology of the complement system into transformative medicines over the past three decades. Today, we continue to push the boundaries of science and deepen our understanding of rare diseases with patient-centricity at the core. This knowledge allows us to innovate and evolve into new areas where needs are unmet and provide an opportunity to help people fully live their best lives.
