Company DescriptionChronological ageing is a biological process that results in accumulated cellular damage, ultimately driving the onset of metabolic disfunction. We aim to develop new therapeutic approaches to these ageing-associated diseases, by targeting metabolism in cancer stem cells (CSCs) and senescent fibroblasts. More specifically, we will screen a series of chemical libraries containing FDA-approved drugs, natural products, and novel chemical entities, to identify compounds that can effectively age-associated metabolic features. Through this screening and validation approach, we will identify compounds that preferentially kill CSCs and senescent fibroblasts, using established cell lines.This position will involve the screening and discovery of drugs that target the metabolic phenotype of senescent cells and cancer stem cells, across multiple cancer types.Job DescriptionThe purpose of this role is to support Lunella Biotech’s mission in the discovery of anti-ageing and anti-cancer therapeutics.ResponsibilitiesTo engage with Lunella’s mission to fight ageing and cancer by developing novel therapeutic strategiesTo develop research objectives in connection with the project outlined above and in agreement with the laboratory headsTo perform experiments in the laboratory to test hypotheses regarding ageing and cancerTo write up draft reports for manuscript publication and patent evaluationTo present data as required, during lab meetings and conferencesTo assist in the supervision of graduate students and staffTo collaborate with members within and outside of the laboratoryTo comply with Health and Safety regulationsTo promote equality and diversity and sustain an inclusive and supportive work environmentThis role detail is a guide to the work you will initially be required to undertake. It may be changed from time to time to meet changing circumstancesQualificationsCompleted PhD in related biological/pharmaceutical sciencesPublication record in peer-reviewed journalsBackground & ExperienceEssential criteriaExperience in flow cytometry/FACS analysis Experience and a track record in working with and developing a variety of techniquesExperience in the generation of stable cell lines using transfection methodsExperience in aseptic techniques for mammalian cell cultureExperience in recording, analyzing and interpreting dataExperience in confocal or fluorescent microscopyDesirable criteriaExperience in assays measuring metabolic parameters of cellular modelsExperience in cell migration and invasion assaysExperience in the co-culture of multiple cell typesExperience in proteomicsExperience in drug screeningSkills & CompetenciesEssential criteriaAbility to work independently within an agreed frameworkExcellent communication skills on paper and verbally, including good IT skillsAbility to work as part of a teamProven ability to follow directionsAbility and willingness to learn new analytical methods and skillsDesirable criteriaGood organizational skillsTo provide guidance to other staff on own specialist areaExperience in writing papers and scientific reportsAdditional InformationAs an equal opportunity employer, Lunella Biotech Inc. is committed to achieving a skilled and diversified workforce that reflects the diversity of the Canadian population. We encourage applications from women, visible minorities, people with disabilities and Aboriginal people.
