VP and Head Clinical Operations, CVRM Possible locations: Boston, MA, Gaithersburg, MD, Cambridge (UK), Gothenburg (Sweden), Mississauga (Canada) Are you ready to lead and inspire a global team in the pursuit of life-changing therapies? We are seeking a visionary VP and Head of Clinical Operations for CVRM (Cardiovascular, Renal, and Metabolic) to drive our clinical operations strategy and execution. As a key member of the Global Clinical Operations leadership team, you will oversee the delivery of therapeutic programs on a global scale, ensuring they meet time, cost, and quality benchmarks. With your deep therapeutic expertise and entrepreneurial mindset, you'll thrive in our science-driven environment, collaborating with SVPs, therapy area leads, and various teams to align CVRM strategies and priorities. Accountabilities: • Provide clear portfolio-level clinical operations expertise to Early and Late TA leadership teams and other internal partners. • Develop, maintain, and implement an operational CVRM strategy with input from internal and external experts. • Establish and direct strategic global leadership for the CVRM Clinical Operations group. • Ensure delivery of operational and clinical development components across the global clinical programs. • Build strong relationships with Senior Vice Presidents of Early and Late CVRM. • Lead all aspects of global delivery of R&D phase I-III clinical trials for the CVRM portfolio. • Collaborate closely with GPT/CPT colleagues around submission strategy. • Communicate business priorities and vision to teams. • Line management and development of executive directors in program management. • Lead cross-functional Operational CVRM leadership team. • Assign capable CVRM Clinical Operations resources to meet project demands. • Develop performance targets and metrics for operational delivery. • Contribute to clinical site strategy and preferred site partnerships. • Represent CVRM Clinical Operations in R&D Governance interactions with C-Suite. • Sponsor non-drug strategy & organizational programs. • Drive global standardization, continuous improvement, and efficiency gains. • Lead and support change initiatives. • Evaluate project performance and support issue resolution. • Identify best practices with other VPs Clinical Operations. • Support due diligence activities as needed. • Develop, coach, mentor, motivate, and inspire individuals within the organization. • Ensure compliance with ethics, policies, and standard procedures. Essential Skills/Experience • Advanced Degree • Scientific background • Extensive knowledge of clinical and pharmaceutical drug development process • Experience working internationally: working with major markets/resolution of international issues • Significant experience in Clinical Development and/or global operational study delivery • Tried experience in project management • Validated line management expertise • Proven business acumen • Professional excellence: Background of high professional achievement and willingness to encourage this in others • Leads change with a positive approach to the challenges of change for self, team and the business. Sees change as an opportunity to improve performance and contribute to the business • Demonstrated development of others, identifying and providing opportunities to improve the capabilities of other people • Output/delivery focused • Demonstrated ability to set and manage priorities, resources, performance targets and project initiatives in a global environment • Cultural Awareness: Is aware of and sensitive to cultural differences and their impact on communication, expectations and performance. • Teamwork and cross functional Collaboration: Is effective in leading and being a member of teams, both locally and internationally. • Excellent communication skills • Willingness to travel domestically and internationally • Demonstrated ability to lead senior level staff • Business planning skills: has knowledge/experience of planning processes used in managing drug projects • Risk and crisis management experience • Experience of leading successful teams from more than one national culture • Manage cost center/department budget and project budget to threshold Desirable Skills/Experience • Preferentially having worked within CVRM (Cardiovascular, Renal, Metabolic) therapeutic area for at least 5 years and can demonstrate deep TA knowledge • Creative and Innovative: Seeks to improve continuously where it counts, based on good awareness of external competitive practice, and creativity and initiative. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and daring world. At AstraZeneca, we are driven by our passion for science and our commitment to making a difference in patients' lives. Our innovative approach combines data, technology, and scientific breakthroughs to take on some of the world's most complex diseases. We champion an inclusive environment where curiosity thrives, empowering our teams to explore new possibilities without fear of failure. By collaborating with academia, biotechs, and industry leaders, we create swift impacts on disease treatment. Join us to push the boundaries of science and build a meaningful career. Ready to make an impact? Apply now to join our dynamic team! Date Posted 12-Aug-2025 Closing Date 27-Aug-2025 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.
