WHY JOIN US? At AstraZeneca, we are dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. With an ambitious goal of delivering 20 new medicines by 2030, there is no better place to make a difference in medicine, for patients, and in society. Join us on this exciting journey to pioneer the future of healthcare. Our inclusive culture champions diversity and collaboration, and we are always committed to lifelong learning, growth, and development. As part of our team, you'll contribute to groundbreaking advancements that will shape a healthier future for people everywhere. Be a catalyst for change at AstraZeneca, where your work will have a real impact on improving people's lives. This is a 100% on-site role based in our lab in Hamilton, Ontario. About the Opportunity Are you ready to make a significant impact in the field of cancer research? We are looking for a dynamic and independent Senior Scientist with a passion for radiopharmaceutical development to join our radioconjugate portfolio team in Hamilton, Ontario, Canada. This role requires a proven track record of scientific excellence and project leadership experience. As a Senior Scientist, you will be the tumor biology technical lead for emerging radioconjugate programs, collaborating with internal teams and external partners to advance novel targeted alpha therapies. This laboratory-based position involves study design, hands-on execution, data analysis, interpretation, and cross-functional communication. You will lead preclinical pharmacology studies and support in vivo evaluations, generating decision-ready data packages to drive preclinical development forward. Accountabilities Serve as an independent technical lead for radioconjugate programs, collaborating with cross-functional teams and external partners to generate critical program data for project milestone decisions. Stay up-to-date with technical, intellectual, and scientific expertise in tumor biology and cancer modeling, particularly related to targeted radioconjugates. Lead preclinical pharmacology studies, including radioligand binding, internalization, and retention assays. Support in vivo biodistribution, imaging, and efficacy evaluations. Plan and conduct in vitro studies and support in vivo studies to generate decision-ready data packages. Analyze and present results to core project teams, prepare materials for governance interactions, and deliver program updates across internal forums. Essentials Skills and Experience PhD Degree with 3+ years of experience, Master’s Degree with 5+ years of experience, or a Bachelor’s Degree with 7+ years and project leadership experience in a relevant discipline related to tumor and radiation biology Demonstrates a strong knowledge of cancer/cell biology, radiation biology, and/or biochemistry in the context of cancer, with a robust desire for continued learning Expertise in routine cell culture, particularly culture of tumor cells Expertise in molecular- and cell-based methodologies, such as cloning/gene editing, cytotoxicity assays, binding and internalization assays, flow cytometry, ELISA, and Western blotting Works independently with minimal supervision to conduct experiments, analyze data, and prepare results for internal and external presentations and regulatory filings Excellent communication, presentation, and interpersonal skills evidenced by a history of successful project delivery in team-oriented, collaborative environments A proven track record of productivity, as demonstrated by scientific publications in high quality peer-reviewed journals Ensures own work, and work of peers, is compliant with Good Laboratory Practice, Safety, Health, and Environment standards and all other relevant internal AstraZeneca standards and external regulations Desirable Skills and Experience Demonstrated proficiency in targeted radiopharmaceutical therapies and/or imaging, and a broad, up-to-date understanding of the field is highly preferred Prior experience in the biopharmaceutical industry and familiarity managing data delivery through contract research organizations preferred Demonstrated ability to coordinate project activities and provide scientific mentorship to junior scientists is highly preferred Direct, hands-on experience in residualization & saturation binding assays, radioimaging (PET or SPECT), biodistribution studies, non-clinical dosimetry, and other pre-clinical radiopharmaceutical methods is highly desirable Experience with targeted alpha emitter therapeutics is an asset SO, WHAT’S NEXT? To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience – it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them. Great People want to Work with us! Find out why: GTAA Top Employer Award for 10 years Top 100 Employers Award Canada’s Most Admired Corporate Culture Learn more about working with us in Canada View our YouTube channel Are you interested in working at AZ, apply today! AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca.com. Date Posted 28-Oct-2025 Closing Date 17-Nov-2025 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.
