At AstraZeneca, we pride ourselves on crafting a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe. Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office and BlueSky Hub in downtown Toronto are purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects. Our dedication to sustainability is also central to our culture and part of what makes AstraZeneca a great place to work. We know the health of people, the planet and our business are interconnected which is why we’re taking ambitious action to tackle some of the biggest challenges of our time, from climate change to access to healthcare and disease prevention. Responsibilities: Plan and deliver observational research and Real World Evidence (RWE) studies in AstraZeneca Canada’s Biopharmaceuticals therapy areas, with a focus on cardiovascular, renal and metabolism Lead the development and execution of comprehensive evidence plans for both pre-launch and launched products to address full breadth of internal and external partners needs Identify and collaborate with key external experts to address identified evidence gaps, including academic-clinical investigators, health outcomes researchers and contract research organizations (CROs) Work collaboratively with Medical Advisors and Market Access colleagues to develop AstraZeneca-sponsored study protocols for local observational (both prospective and retrospective) studies, as well as review and advise on externally sponsored research proposals Identify and evaluate new health database and disease registry opportunities in Canada that could be used for real world studies in therapy areas of interest Liaise with global counterparts for all evidence generating activities and lead the review and approval process for local studies at AstraZeneca Canada Drive local and global study teams in order to deliver project-specific achievements and resulting scientific publications (e.g., conference presentations, peer-reviewed journal manuscripts) according to timelines (e.g., HTA submission target) Develop and manage communication and knowledge translation plan for all evidence generating activities and ensure presentation of study results to appropriate partners (e.g., HTA meetings) Lead site start-up activities such as ethics submission, informed consent review, development and finalization of research study agreements and follow-up and maintenance of all study related activities, if required, in accordance with AstraZeneca and international regulatory requirements. Develop and maintain study budget, timelines and resources and ensure appropriate updates are made to internal tracking systems Prepare, implement, track, collect, review and assess study documents and ensure their completeness according to external guidelines and AstraZeneca SOPs Complete study feasibilities for Global Non-Interventional Studies in collaboration with the local team and global counterparts Provide in-house epidemiology, statistics, and observational research methodology expertise to cross-functional partners, including Medical, Market Access and Regulatory teams. Qualifications: Master’s degree or PhD in epidemiology, health research methodology, biostatistics and/or data analytics required). Experience leading RWE studies in multiple therapy areas is required Understanding of statistical principles and methodologies applicable to observational and other types of real-world studies (eg pragmatic trial design) Experience in data analytics and/or ability to work with different health databases an asset Excellent understanding of observational study methodology (design and interpretation) and externally sponsored research including clinical and pre-clinical research Demonstrated track record in observational research, demonstrating both strategic and tactical elements Demonstrated leadership ability in a team environment Experience in project management Excellent interpersonal, verbal and written communication skills Self-motivated and able to display autonomy and initiative – for instance; able to take action, move actions forward and make decisions without the need for continual supervision or consultation. Ability to interact with key external customers, including governments, payers, academic researchers and physicians Effective time management skills Good knowledge of MS Office (Word, Excel, PowerPoint) Knowledge of French is an asset Medical Evidence Manager: 1-2 years direct experience in leading RWE studies in different therapeutic areas. The Medical Evidence Manager will have specific study leadership responsibility, working directly with the MEL. Great People want to Work with us! Find out why: GTAA Top Employer Award for 10 years Learn about our culture Learn more about working with us in Canada View our YouTube channel Are you interested in working at AZ, apply today! AstraZeneca is an equal opportunity employer that is committed to diversity and inclusion and providing a workplace that is free from discrimination. AstraZeneca is committed to accommodating persons with disabilities. Such accommodation is available on request in respect of all aspects of the recruitment, assessment and selection process and may be requested by emailing AZCHumanResources@astrazeneca.com. Date Posted 03-Dec-2025 Closing Date 03-Dec-2025 AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world’s most serious diseases. But we are more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We’re curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We’re driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you’ll do work that has the potential to change your life and improve countless others. And, together with your team, you’ll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.
